Endometriosis Knowledgebase

PMID	16084898
Gene Name	IL18
Condition	Endometriosis
Association	Associated
Mutation	IL-2R beta-627*C homozygote, IL-12R beta 1 codon 37, IL-18 105
Sex	Female
Associated genes	IL-2R beta, IL-18
Other associated phenotypes	Endometriosis
*Interleukin-2 receptor beta (IL-2R beta)-627C homozygote but not IL-12R beta 1 codon 378 or IL-18 105 polymorphism is associated with higher susceptibility to endometriosis.** Fertil Steril. 2005 Aug;84(2):510-2. Hsieh, Yao-Yuan\| Chang, Chi-Chen\| Tsai, Fuu-Jen\| Hsu, Chin-Mu\| Lin, Cheng-Chieh\| Tsai, Chang-Hai Department of Obstetrics and Gynecology, China Medical University Hospital, Taichung, Taiwan. Interleukin (IL)-2 R-627C homozygote and C allele are related to higher susceptibility to endometriosis. Interleukin-12Rbeta1 codon 378 and IL-18 105 gene polymorphisms are not correlated with endometriosis development. Mesh Terms:* Alleles\| Cytosine\| Endometriosis/genetics\| Female\| Genetic Predisposition to Disease\| Homozygote\| Humans\| Interleukin-18/genetics\| Interleukin-2 Receptor beta Subunit\| Polymorphism, Genetic/genetics\| Receptors, Interleukin/*genetics\| Rece